ANtimicrobials Quiz Prometric

1) Which of the following describes the route of transmission of corona virus?

2) Which of the following is the mechanism of action of Quinolones?

3) Which of the following medications can alter renal function?

4) Which of the following microorganism causes typhoid fever?

5) An 18 months infant with a H/O premature birth and chronic lung disease is admitted to the PICU with fever, respiratory distress necessitating intubation, 3days H/O cold like symptoms. The results of a nasal swab are positive for RSV. Which is the best ttt?

6) During RSV season, which patient is the best candidate for the use of Palivizumab for RSV prophylaxis?

7) Which statement about prophylaxis of bacterial meningitis is the most accurate?

8) A physician asks for your recommendation for treating a 5 YO child with his 1st case of acute otitis media. Which statement is the best advice?

9) A 5-month infant who was born at term and is otherwise healthy. On F/Up examination, her pediatrician noticed fullness in the middle ear and a cloudy tympanic membrane with decreased mobility. She is now afebrile and eating well. Which is the best recommendation for him?

10) A 28 YO woman who presents to the clinic with a 2 days’ history of dysuria, frequency and urgency. She has no significant medical history, and the only drug she takes is oral contraceptives. Which is the best empiric therapy for her case?

11) A 38 YO woman who presents with a fever, malaise, dry cough, nasal congestion, severe headache. Her symptoms began suddenly 3 days ago, and she has been in bed since then. She reports no other illness in her family, but several people have recently called in sick at work. It is influenza season. Which is best for her case?

12) A 52 YO man who comes to the hospital with a 3-day H/O fever, chills, chest pain, malaise, and productive cough. His temperature is 38.9°C, all other vital signs are normal. His chest radiograph reveals consolidation in the right lower lobe. His WBC is 14,400 cells/mm3, but all other laboratory values are normal. He is given a diagnosis of CAP. He has not received any antibiotics in 5 years and has no chronic disease states. Which is the best empiric therapy for his case?

13) Antiretroviral treatment affords the following benefits in HIV infection except?

14) TB infection in a HIV infected patient is treated with?

15) The characteristic toxicity of ethambutol is?

16) Which of the following antitubercular drugs is not hepatotoxic?

17) A patient with pulmonary tuberculosis treated with Rifampin + INH + Pyrazinamide developed paresthesia, weakness, dizziness, ataxia and depressed tendon reflexes. Which of the following measures would you recommend?

18) Regarding INH, it has the following advantages except?

19) A 36 YO man not known to have any medical illness diagnosed recently with an active pulmonary TB. Which of the following is the best regimen to start?

20) The most important reason for using a combination in the treatment of TB is?

21) A pregnant with HIV and viral load >100 copies/ml, which medication is given in delivery?

22) Choose the correct statement about Famciclovir?

23) Ganciclovir is preferred over acyclovir in the following condition?

24) The most probable mechanism of action of imidazole antifungal drugs is?

25) Select the antifungal drug which is administered only by the oral route?

26) Griseofulvin is indicated in?

27) The newer lipid formulations of amphotericin B differ from the conventional formulation in the following respects except?

28) The most important toxicity of amphotericin B is?

29) The polyene antibiotics act by?

30) Which antifungal can be used by oral or IV administration for treatment of systemic infection?

31) A pregnant woman is travelling to a country with high malaria risk. Which antimalarial prophylaxis caries the most fetal risk in pregnant women?

32) A 7 YO boy presents with complain of itching around the anus at night. Lab tests revealed Enteroblus vermicularis infestation. Which of the following is the most appropriate management?

33) A 6 YO child is diagnosed with a pin worm infection. Which of the following is the best drug of choice for his case?

34) A 65 YO diabetic man admitted to ED with a 3-day H/O productive cough, SOB and chest pain. CXR showed bilateral lower infiltration. An H1N1 virus was detected in nasal swab. Which of the following antivirals is the drug of choice in this case?

35) Which of the following medications would inhibit uncoating of the viral RNA?

36) Which of the following clinical conditions is treated with Zanamivir?

37) Which one of the following can cause latent infection?

38) A 60 YO woman is admitted to the hospital for surgery. Colonization of gram-negative bacteria occurred after surgery. Which of the following is the best management?

39) Which of the following infections is prevented with the administration of 0.5% Erythromycin eye ointment in newly born infants?

40) Which of the following might develop in association with high serum amikacin?

41) A 28 YO pregnant female in labor is admitted to the hospital. She tested positive for Group B Strept. colonization at her 36-week gestation. She has a severe penicillin allergy & her culture is resistant to both clindamycin and erythromycin. What is the recommended treatment for this patient?

42) What is the recommended prophylactic therapy for pregnant women colonized with GBS in labor with penicillin allergies at high risk for anaphylaxis?

43) A 23-month infant, his weight is 14 kg, his mother brought him the hospital with signs & symptoms of bacterial meningitis. The baby attends day care and has a H/O acute otitis media. A blood and CSF culture were ordered and pending. Which of the following is the empirical therapy for acute bacterial meningitis?

44) Which of the following can be used for UTI infections?

45) Which of the following classes of medications have been associated with the development of newborn kernicterus when used by pregnant women at full- term?

46) Which of the following medications can cause hemolytic anemia in the newborn when used by a pregnant woman at full term?

47) Which of the following is the reason doxycycline should be avoided in children less than 12 years?

48) Which of the following conditions is a serious adverse reaction of fluoroquinolone therapy?

49) A 57 YO man who presents to an ED with complains of 2-day H/O high fever, muscle/bone ache, headache and loss of appetite. He reports that he is contacting of a sick friend with flu recently, otherwise he is healthy. Which of the following would be the best management?

50) Which of the following antibiotics is used in surgical prophylaxis of colorectal surgeries?

51) An ESKD patient has an infection with, what is your recommendation for his case?

52) A pregnant woman has sulfa allergy, she suffers from vaginal itching. Her doctor performs urine analysis & vaginal swab. Her Lab. results reveal presence of E.coli, what is the antibiotic of choice for her infection?

53) Which of the following tests should be performed prior to infliximab?

54) A patient went for tooth extraction, the doctor need to prescribe an antibiotic as a prophylaxis from endocarditis. Which one of the following it is mostly indicated?

55) Which one of the following can be used topical for MRSA?

56) Target vancomycin trough level in severe infection is?

57) Which of the following drugs has poor oral bioavailability?

58) A nurse has an inquiry about the appropriate time to withdraw a trough gentamicin level for a patient. What is the best answer for her inquiry?

59) An 18 YO healthy girl admitted to the hospital with a diagnosis of necrotizing pneumonia. She received vancomycin 1 g IV Q12h and Meropenem 1 gm IV Q8h. The trough level of vancomycin was 16 mcg/ml. Which of the following is the next appropriate step in management of this patient?

60) A patient has severe endocarditis with Stap.aureus on vancomycin but sensitivity test is done and the patient is only sensitive on linezolid but it's not FDA approved in endocarditis what's the management?

61) Which of the following is the most appropriate empiric treatment for a patient with CAP requiring admission to the hospital?

62) A patent taking Vancomycin 1gm Q12h, infusion rate 1 g/h he developed skin rash and redness. what is the best course of action?

63) Maximum infusion rate of Vancomycin?

64) A red man syndrome has been associated with rapid IV injection of the following antibiotic?

65) A patient on Vancomycin infusion, when nurse can withdraw a trough level for him?

66) Your colleagues has been contacted with C.diff patient and used disinfectant wipes, what to do?

67) Oral vancomycin is indicated in the following condition?

68) Highest incidence of antibiotic associated pseudomembranous enterocolitis has been noted with the use of?

69) Which of the following Clostridium spp. is linked to the develop pseudomembranous colitis?

70) Acidic urine augments the antibacterial action of the following drug?

71) Features of clindamycin include the following?

72) A premature neonate suffered respiratory distress and was given an antibiotic. Over the next 2 days his condition worsened, he become dull, stopped feeding, developed abdominal distention and a gray appearance. Which is the most likely antibiotic given to him?

73) Ciprofloxacin is not active against?

74) Pt with E.coli UTI and given TMP/SMX but it turns out to be resistant what is the most appropriate alternative?

75) The most suitable tetracycline for use in a patient with impaired renal function is?

76) Which antibiotic causes hyperkalemia?

77) A patient with mild sore throat without any other S&S of infection. What is your advice for his case?

78) Which of the following is the best treatment for Staph.aureus positive mastitis?

79) Which of the following is the drug of choice for chlamydia infection?

80) Which of the following best describes ceftazidime?

81) The drug of choice for treatment of methicillin resistant Staphylococcus aureus infection is?

82) The following is true of sulfonamides except?

83) Cholestatic jaundice occurs most frequently with which of the following Erythromycin preparations?

84) The most frequent side effect of oral Ampicillin is?

85) Amoxicillin is inferior to Ampicillin for the treatment of?

86) Benzathine penicillin is taken by a patient once every 4 weeks, what is the possible indication?

87) If a patient gives H/O urticaria, itching and swelling of lips following injection of Penicillin G, then?

88) Which of the following is not an indication for prophylactic use of antibiotics?

89) Which of the following has similar antibacterial mechanism of penicillin?

90) Which of the following mechanisms, cephalexin exerts antibacterial effects?

91) The most important mechanism by which Tetracycline antibiotics exert antimicrobial action is?

92) Which one of the following antimicrobial agent acts by interfering with DNA function in the bacteria?

93) Antibiotic which inhibit protein synthesis by binding with 50S will inhibit?

94) Antibiotic which inhibit protein synthesis by binding with 30S will inhibit?

95) Which of the following bacteria is involved in the development of dental carries?

96) Superinfections are more common with?

97) A patient performs CBC & other Lab. investigations, his results all normal except high WBCs. What is your suggestion?

98) Most effective infection control measures in hospital?

99) What is correct regarding Ebola Virus?

100) What are the major constituents of the fungal cell wall?